The Potentiality Of ß- Carotene As Free Radicalscavenger:A Study Of The Raise Of Superoxide Production Inmitochondrial Lymphocyte

Abstract: This is a study on carotenoid extracted from ‘Minyak Buah Merah' (Pandanus conoideus) in therapy simulation usinghigh dose of β-carotene on two lymphocytes-that of a healthy subject and a leukemia patient. Superoxide productionin mithocondrial lymphocyte as a result of β-carotene exposure was examined using a flow cytometer. The test findsthat superoxide (a specific mitochondrial free radical) increases easier and faster in leukemic lymphocytes than innormal lymphocytes. The results of the study support previous meta-analysis studies that high dosages of β-caroteneand vitamin E supplements as antioxidant should be discouraged because it increases all-cause mortality.